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Driving your success.. Progression-free and overall survival in relation to changes in sTK1 levels. The estimated HRs above correspond to a fold decrease in sTK1 levels. To further evaluate changes in sTK1 activity levels over time between the different treatment groups, we analyzed median levels of sTK1 activity in subgroups of patients based on fortskridande at evaluations at 3 and 6 months versus non-progression. We found that sTK1 levels were initially reduced at 1 month in ET treated patients irrespective of therapy response Table  S4. However at follow-up time points at 3 and 6 months, increasing sTK1 levels were observed in patients with progression whereas patients with non-progression had continuously reduced sTK1 activity levels at all time-points Table  S4. When analyzing patients treated with ChT, sTK1 levels were initially increased at 1 month in patients irrespective of therapy response. However, at longer follow-up time points at 3 and 6 months sTK1 levels were continuously increased in patients with progression whereas sTK1 levels in patients with non-progression started to decrease from 3—6 months Table  S4. Further, sTK1 is prognostic for survival during therapy by landmark analyses up to 6 months.



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